My rifle is a BLR 81 bought new as a .22-250 in the late 1980's. I had master metal smith, Ron Lampert rebarrel with a 22 inch Douglas premium. At 35 grains, the cartridge(s) still extract easily and as stated before little or no change in brass dimension.
I'm currently working up a new load for my .250 Savage. I'm using W-W cases, Remington 91/2 primers and Nosler 100 gr BT. I see the Hodgdon manual recommends up to 35.2 gr with a Hornady bullet. I've loaded cases at 33.5, 34, 34.5 and 35 gr of Varget and showing no signs of pressure in the brass...