My 300 Win Mag likes 77.5grs of Reloader-22 with 180's @3100fps.As always start lower and work your way up.My rifle seems to shoot better with max loads in all the powders and bullet weights I've tried.
Another powder that will get your velocity up there is Reloader-17.I tried some with 180's in my 300 Win Mag and I got very good results in my load test.71.0grs gave me around 3100fps,but groups were not all that great.72.0grs gave me 3150fps and much tighter groups.Next time out to the range I loaded 72.5grs and got 1/2" groups @ a sizzling 3215fps!Now that's moving a 180gr bullet!
Not seeing any pressure signs and that's what scares me about it.That Reloader-17 is a different powder than what we are used to.It is made by the Swiss and they use a different process in the making of this powder that gives you higher velocities with lower pressures.You can load it very close to IMR-4350,but I would start out with at least 1gr less than what your loading with IMR-4350 and work your way up.