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thanks, what is an "air buffalo"? Also where would i get these bullets? Any thoughts on why the Nosler 45 don't seem to work?

The 35 cal usually penetrats thru the entire spinal column exisitng the other side . The 45 cal stay in the animal. I guess the difference is the 45 cal seems to not penetrate the vertibra thereby not hitting the spinal column and its fuild that transfers the hydraulc shock wave to the brain...

I raise and slaughter buffalo ( bison). Each year in the fall, I kill 3-8 animals. The range is short; 25 yards. The shot is always a neck shot just behind the skull. I started shooting using my 35 Whelan using 225 or 250 grain bullets usually factory loads by Federal or Winchester. If I do my...