I called IMR (hodgdon) tech line about using 4166 in my .220 swift as there isn't any data out yet. They had suggestions for starting points. They'll likely due the same for you. The man I talked to was very knowledgeable and was very big on the Enduron powders. I sure wish I could find some of that 4451 in my area.
Sad. They didn't offer any suggestions about the combination. Wish QuickLoad was updated with the Enduron powders.
I have noticed in the 300 WSM, IMR 4350 runs a couple of grains more than the IMR 4451. Could one extrapolate based off of load data for IMR 4350 in the 325 and work closely with the chronograph to find their way? How do wildcaters do it?