If one can and will use ear protection at all times I think a 338 RUM or 338-378 with a muzzle brake would be fine! I chrono'd a 33-378 for a guy with a muzzle brake and I swear it kicked no more than my 270 winchester. My son unscrewed the brake and took a shot, then said "never again". The reason I went back down to the 300 Weatherby from the bigger guns is- I have never been attacked by a charging grizzly. If the animal-huggers get their way we will have them down here in Oregon, along with the wolves and cats! A cougar attacked my dog right behind my home a while back and a 338 RUM would have put just the right size hole in that cat!