I never had a problem running 180 gr. Sierra round nose bullets in either the .308or 30-06 on deer. Never recovered any of those bullets as they all passed through the animal. Deer usually dropped on the spot.I'd be a little cautious with a round nose in a bigger centerfire like a 30-06 and above if your pushing the velocity for big game. Using one meant for 30-30 velocities could be...interesting. Personally I'd run some in milk jugs to see how they perform at the velocity and distance you plan on using them at.
Paul B.
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