I have a load worked up for my 300 WSM with a 165 BT with 64 gr of IMR-4831 and got the best results with a CCI large rifle primer, will using a large rifle primer instead of a mag primer decrease the velocity? I tried CCI 250, Fed 215 and WLRM primers.
You might see a change in velocity, but I wouldn't worry about it if the load with the CCI large rifle primer is accurate. Just about the only situation I could imagine where I'd be concerned would be if I hunted a lot in extremely cold temps. In those kinds of conditions, I'd try to find a load with a mag primer just for the extra brisance to give more consistent ignition. If you're not routinely hunting in Alaska in the bitter cold, or some parts of the northern plains states or mountain west during the throes of winter, I don't imagine it would be a big deal.
Generally speaking, a regular rifle primer will generate less pressure than will a magnum primer. The difference may not be significant, however. In the short magnums, because of the shorter powder column, I prefer to use regular rifle primers rather than magnum primers. There is more than enough fire to ignite the powder. The major exceptions (other than when an individual insists that I develop his load with magnum primers) are if I am using spherical powders or if the hunting/shooting will be in exceptionally cold weather (I arbitrarily set that condition as colder than -15 C). The load you have selected is one of the finest I can imagine. I often use F210 or CCI200 primers and IMR4831 with 165/168 grain bullets. I get great accuracy and velocities that approximate those reported by bullet and powder manufacturers. If you choose to use magnum primers, you will get slightly more velocity, but the increase is not as great as some might imagine.
The guys are right, LRP will fork fine unless you are shooint in sub zero temps. I wouldn't worry about velocity and the difference won't be enough to make a difference. Focus on accuracy and the ability to place the bullet with surgical precission.