When I'm shooting 300 grain loads, I generally stick with 55 grains of H4198. This jumps out of the 22" barrel at 2280 fps with decent accuracy and modest recoil. Normally I just practice with the far less expensive 300 grain Remington JHP's, which are a pretty good bullet, but the Nosler has an awesome reputation for deep penetration & game killing performance.
I think "Reflex" posted some good photos here of a guy who used the 300 Nosler in Africa sometime during this past summer. Believe he was only using 51 grains of H4198 for very good performance at 1950 fps from the 18" barreled Guide Gun.
Hodgdon lists the 55 gr H4198 charge at the top of their "Trapdoor" loads and as the starting point with their "Lever Action" loads - but that's with the 300 grain Sierra. I'd expect the 300 grain Nosler Partition to be a little different w/respect to pressure & velocity because of the different bullet construction.