I know a guy that for yrs used a 22-250 with just factory 55 gr soft points. Winchester I believe. Anyways just a type of bullet that would be considered a medium heavy varmint bullet.
Broadside shots behind the shoulder, and according to him the results were always pretty much straight down. I can't imagine the bloodshot mess it made. But if a 55 gr sp will do it, your bullet certainly will hold together better. Blood shot might still be extreme.