I have had several guys whom I consider to be some what reliable tell me that I should use my 22-250 for Antelope. Two, in particular, tell me that Federal Vital-shock factory rounds with the 60 grain Partition bullets are all I need. I reload so I am not limited to factory rounds but I want to put the question to the Nosler guys: Is the 22-250 a valid caliber for Antelope out to 300 yards unless the wind is blowing gale force? If so, is the 60 Grain Partition the best choice. I use partitions for the 30.06 and the 300 Win exclusively - I AM a believer.