I would even look a little more at the 225gr AccuBond. I use the same bullet out of my 338 Win Mag and it is very accurate and shoots very flat. I would think you could get 2600-2700 out of the 225 AccuBond out of the 338-06 without any issues, still have a great, flat flying bullet with alot of Sectional Density. I would be very confident using that set up for encountering a big brown at close range. Scotty