I have used the 375 H&H on African Plainsgame of all sizes for camp meat, The 300 gr. bullets are tough for use on Cape Buffalo and as such, they are great on the smaller stuff as they don't expand violently and tend to just cut a good size hole, a quick kill, exit hole the size of a quarter, mostly instant kills but some may run 25 to 50 yards as with any caliber, but always a good blood trail.
Lighter higher velocity bullets tend to be very destructive, especially if bone is encountered...I would suggest a 300 Sierra BTSP or the 300 gr. Hornady...Actually there is no such thing as bullet failure with a 300 gr. .375 at 2500 FPS. You will have less bloodshot meat with a 375 than with a 243 or 270.
Lighter higher velocity bullets tend to be very destructive, especially if bone is encountered...I would suggest a 300 Sierra BTSP or the 300 gr. Hornady...Actually there is no such thing as bullet failure with a 300 gr. .375 at 2500 FPS. You will have less bloodshot meat with a 375 than with a 243 or 270.