Shot this nice buck a few weeks ago with a 257 Weatherby Vanguard series 2 and a hand loaded 100 gr. TTSX .I have never chrono'd this load but I suspect it's in the 3450 fps range and very accurate .Shot was 250 yards quartering to me. I hit him angling in through the scapula , through the right lung , liver , stomach and was found in the left ham resting on the femur. Hole through the lungs and liver appeared to be about 1.5" . He gave no indication he was hit at all , much to my dismay, and just tore off. I'm not sure when the pedals broke off but it went though 3 feet of deer.